Specific genetic variations (C>T polymorphism) in the TIMP4 gene have been associated with a protective effect against preeclampsia in pregnant women. TIMP4 vs. Other TIMPs
While TIMP1, 2, and 3 are expressed widely, TIMP4 is expressed in a more tissue-specific manner. It acts as the major intraplatelet MMP inhibitor, playing a key role in regulating platelet aggregation. Conclusion: Future Therapeutic Potential
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Mice lacking the TIMP4 gene showed increased inflammation, indicating its anti-inflammatory role in diseases.
TIMP4 is highly expressed in human cardiovascular tissue, particularly within adipose tissue. Specific genetic variations (C>T polymorphism) in the TIMP4
TIMP4: The Molecular Guardian of Matrix Integrity and Emerging Disease Marker
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Recent studies in 2025 demonstrate that .