[s4e2] Love/addiction -

Watch a recap of the episode's themes and major character developments here:

George struggles with his guilt after admitting he loves Izzie, while Callie, as Chief Resident, is overwhelmed by her duties and her suspicions that George is cheating. [S4E2] Love/Addiction

Meredith and Derek continue their "friends with benefits" arrangement, which Derek eventually admits feels more like an addiction than a healthy relationship. Watch a recap of the episode's themes and

The residents and interns treat victims of a massive apartment fire caused by a meth lab explosion. Alex Karev deals with a particularly difficult case involving a baby who suffered a stroke due to the meth lab environment. as Chief Resident

Meredith's half-sister, Lexie, attempts to bond with Meredith, who remains resistant to having a relationship with her.