[s4e16] House's Head | (part 2)

In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure.

: The episode concludes with Thirteen testing positive for Huntington’s disease, echoing the theme that life is often "unfair" and beyond a doctor's control. [S4E16] House's Head (Part 2)

: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship. In the second part, "Wilson's Heart," the team

: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend. Wilson is left alone, finding a final note

: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes