Izzie Stevens (Katherine Heigl) attempts to host a traditional Thanksgiving dinner at Meredith's house, but she struggles when it appears none of her invited guests will show up.

The holiday forces the interns and residents to confront their various personal tensions:

refinery29.com/en-us/2020/11/10184919/greys-anatomy-thanksgiving-episodes-to-rewatch">Thanksgiving-themed episodes ?

"I like Thanksgiving. Day people spend with their families. Too much family time triggers depression, repressed childhood rage, bitter disputes over the remote and way too much alcohol. People get stupid. People get violent. People get hurt." —

Meredith Grey (Ellen Pompeo) uses the hospital as an escape from the holiday and treats Holden McKee , a patient who has been in a vegetative state for 16 years.

The episode's opening and closing monologues focus on the concept of , citing Benjamin Franklin's advice to "never leave that till tomorrow which you can do today". It highlights that fear of failure or mistakes often stops people from making decisions. Notable Quote: