: Rare cases and legal challenges have linked long-term use to chronic kidney disease, leading to substantial litigation settlements. 6. Market History and "Chiral Switch"
Prilosec was once the world's best-selling prescription drug. Facing patent expiration in the early 2000s, manufacturer AstraZeneca employed a "chiral switch" strategy by launching (esomeprazole), the purified S-enantiomer of omeprazole, to maintain market share. prilosec
: Some studies link long-term PPI use to an increased risk of bone fractures. : Rare cases and legal challenges have linked