: APL is typically characterized by a chromosomal translocation,
: Depending on where the breakpoint occurs in the PML gene, three main types of fusion transcripts are formed: Long Form (L-form) : Breakpoint in PML intron 6. Short Form (S-form) : Breakpoint in PML intron 3. Variable Form (V-form) : Breakpoint in PML exon 6. PG.rar
: Identifying the "long form" via techniques like RT-PCR or Southern blot analysis helps clinicians confirm the diagnosis and monitor the patient's response to treatments like all-trans retinoic acid (ATRA) . : APL is typically characterized by a chromosomal