The pathology and genetics of urinary system tumours have been significantly updated in the . This latest "Blue Book" shifts the focus toward a more molecular-driven classification while maintaining morphology as the diagnostic groundwork. Key Updates in the 5th Edition
WHO/ISUP grading is now recommended for all RCCs. For bladder tumours, any presence (even ≥is greater than or equal to
Several renal tumours are now defined by their genetic alterations, such as SMARCB1-deficient medullary renal cell carcinoma (RCC), TFEB-altered RCC, and ELOC-mutated RCC.