Arizona handed the 49ers a humiliating 47–24 loss, which sealed San Francisco's "disastrous" 6–11 season and secured them the No. 11 pick in the draft. Kyler Murray threw four touchdowns in the blowout.
The and San Francisco 49ers have a storied NFC West rivalry, with the 49ers currently leading the all-time series 38–31 . Recent Series Recap (2024–2025 Seasons)
The dynamic of this rivalry shifted significantly during the 2024 season, which saw Arizona complete a rare sweep of San Francisco. NFL San Francisco 49ers vs Arizona Cardinals
The 49ers "crushed" the Cardinals 41–22 . Brock Purdy threw three touchdowns, and Christian McCaffrey found the end zone three times. Historical Series Statistics
A gritty 16–15 defensive battle that went to San Francisco. Arizona handed the 49ers a humiliating 47–24 loss,
The 49ers regained momentum in the 2025 campaign, winning both matchups:
According to the 49ers–Cardinals rivalry history , the series is defined by long streaks of dominance. San Francisco 49ers Arizona Cardinals 38 Wins Longest Win Streak 5 Games (Three times) 8 Games (2015–2018) Largest Victory 50–14 (2003) 47–7 (2015) Playoff Meetings Key Rivalry Trends The and San Francisco 49ers have a storied
The Cardinals overcame a halftime deficit to stun the 49ers 24–23 at Levi's Stadium. This game set a record for the hottest regular-season kickoff at the stadium at