If you are trying to mod a game, you would generally use a tool to extract the ISO contents, modify the files, and then rebuild the ISO.
The file might be mislabeled or misidentified. General Guide for Handling Unknown .iso Files Newstar Richie.iso
To play or test, you would use an emulator (e.g., PCSX2 for PS2, PPSSPP for PSP). 4. Where to Find Help If you are trying to mod a game,