To determine if combining NPS (PGX) with sitagliptin reduces hyperglycemia in Zucker diabetic fatty (ZDF) rats better than either treatment alone [17]. 2. Methodology
Sitagliptin increases GLP-1, enhancing insulin secretion [17].
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Obese Zucker diabetic fatty (ZDF) rats (a standard model for type 2 diabetes). Groups: Control (Cellulose/Vehicle). NPS (5% wt:wt) + Vehicle. Cellulose + Sitagliptin [10 mg/(kg · d)]. NPS (5%) + Sitagliptin [10 mg/(kg · d)]. To determine if combining NPS (PGX) with sitagliptin
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A highly viscous dietary fiber [18, 19]. NPS (5% wt:wt) + Vehicle
Potential for a superior nutritional/pharmacological combination therapy for humans with T2D.