Kp2.pdf <2025>

The KP.2 SARS-CoV-2 variant, a descendant of the JN.1 lineage (labeled JN.1.11.1.2), is characterized by spike protein mutations R346T, F456L, and V1104L, which contribute to higher transmissibility. Identified as a "FLiRT" variant under monitoring, it presents with typical Omicron symptoms but shows increased fitness, driving its dominance in early 2024. For more on the virological characteristics, see bioRxiv . What to Know About COVID FLiRT Variants | Johns Hopkins