: As of 2026, Ellen Pompeo , Chandra Wilson (Miranda Bailey), and James Pickens Jr. (Richard Webber) are the only original cast members still appearing on the show.

: The series remains a massive cultural staple and was recently renewed for a 23rd season . Iconic Quotes

: The show masterfully blends intense medical cases with complex relationships and emotional personal growth .

premiered on March 27, 2005, and has since become the longest-running primetime medical drama in TV history. Created by Shonda Rhimes , the series initially centered on Meredith Grey (portrayed by Ellen Pompeo ) and her fellow interns—Cristina, Izzie, George, and Alex—at Seattle Grace Hospital. Series Overview

: Over 20+ seasons, the hospital has been renamed several times, eventually becoming Grey Sloan Memorial Hospital .