G9048.mp4 Apr 2026

: Time-lapse footage of cancer cells moving across substrates of varying stiffness.

: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells. g9048.mp4

: Observations of "leader cells" responding to GLI2 inhibition. : Time-lapse footage of cancer cells moving across

: This "chemo-mechanical" loop promotes cell proliferation, migration, and the transition of normal cells into invasive cancer cells. Potential Video Content g9048.mp4

The research, published in journals such as and archived on PMC , explores how tissue stiffness and biochemical signaling work together to drive cancer growth. Key Research Findings