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A provisional category for cases that do not meet the strict criteria for SMZL or SDRPL. 3. Diagnostic Approach

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Currently considered the first-line standard of care, offering high response rates with low toxicity. A provisional category for cases that do not

Peripheral blood smears often show "villous" lymphocytes (small cells with polar cytoplasmic projections). Immunophenotyping: Flow cytometry typically reveals Advances in molecular profiling and the success of

Splenic lymphomas remain a diagnostic challenge due to their rarity and overlap with other indolent B-cell neoplasms. Advances in molecular profiling and the success of anti-CD20 monoclonal antibodies have shifted the treatment paradigm away from invasive surgery toward targeted medical therapy. Suggested Resources for PDF Download