: Enlarged fluid spaces in the deep white matter.
: Specific patterns of white matter damage. Clinical Significance : Enlarged fluid spaces in the deep white matter
The "next generation" of cerebral amyloid angiopathy (CAA) diagnosis is defined by the , released in late 2022 to replace the 2010 modified criteria. This update shifts the diagnostic paradigm from purely hemorrhagic markers to a more holistic "small vessel disease" profile, integrating white matter signatures. Key Evolutions in the Next Generation Criteria This update shifts the diagnostic paradigm from purely
The Boston criteria version 2.0 for cerebral amyloid angiopathy : The minimum age for applying the criteria
: While lobar intracerebral hemorrhage (ICH) and microbleeds remain central, cortical superficial siderosis (cSS) and convexity subarachnoid hemorrhage are now prioritized. Multiple separate foci of siderosis can now qualify a patient for a "probable CAA" diagnosis on their own.
: The minimum age for applying the criteria has been lowered from 55 to 50 years .
