A healthcare professional must confirm a diagnosis of depression or anxiety before starting treatment. Over-the-Counter Antidepressants - Verywell Mind

, you cannot buy FDA-approved antidepressants over the counter . In the United States , medications such as SSRIs (e.g., Zoloft, Prozac) and SNRIs require a prescription from a licensed healthcare provider. Why a Prescription is Required

Antidepressants are regulated because they significantly alter brain chemistry and require professional supervision for several reasons:

Providers must monitor for potential side effects and interactions with other medications.

Finding the correct dosage often involves medical assessment and follow-up care.