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Trifexis is a prescription medication and cannot be legally purchased in the U.S. without authorization from a veterinarian.

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As of early 2026, a direct generic equivalent for Trifexis (spinosad + milbemycin oxime) has not been released to the market. Active Ingredients: Spinosad: Targets and kills adult fleas. Trifexis is a prescription medication and cannot be

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