Elevated AFP levels may indicate neural tube defects (such as spina bifida or anencephaly), abdominal wall defects, twin pregnancy, or an incorrectly estimated gestational age.
The maternal serum AFP (MSAFP) test is a blood test performed during the second trimester (typically between 15 and 20 weeks) to assess the risk of fetal abnormalities. alpha fetoprotein
It is a screening test, not a diagnostic one. A positive screen does not mean a definite abnormality; further diagnostics, such as an ultrasound or amniocentesis, are usually required. 2. Alpha-Fetoprotein (AFP) as a Tumor Marker Alpha-Fetoprotein (AFP) Test: MedlinePlus Medical Test Elevated AFP levels may indicate neural tube defects
Lower than normal levels may indicate Down syndrome (trisomy 21) or Edwards syndrome (trisomy 18). A positive screen does not mean a definite
1. Alpha-Fetoprotein (AFP) in Pregnancy (Prenatal Screening)
Alpha-fetoprotein (AFP) is a protein produced primarily by the liver and yolk sac of a developing fetus during pregnancy. While levels are high in fetuses and decrease significantly by age 1, AFP testing is used in two distinct medical contexts: prenatal screening and tumor marker monitoring.