A fragment of Collagen XVIII that acts as a potent angiogenesis inhibitor . It prevents the formation of new blood vessels that feed the tumor. Therapeutic Potential
Its role is complex. While high serum levels often correlate with poor prognosis and metastasis, it can also act as a protective factor against inflammation-driven tumorigenesis in early stages. 27879.rar
A critical diagnostic marker. It is virtually absent in healthy adult livers but highly expressed in HCC. It promotes tumor growth by stimulating the Wnt and IGF signaling pathways. A fragment of Collagen XVIII that acts as
💡 Proteoglycans are no longer seen as just "cellular glue." They are dynamic regulators of the tumor microenvironment that determine how fast a tumor grows and how it responds to treatment. While high serum levels often correlate with poor
Proteoglycans (PGs) are heavily glycosylated proteins found in the extracellular matrix (ECM). In the context of liver cancer, they act as a "double-edged sword," either promoting or inhibiting tumor progression depending on their specific type and the stage of the disease. Key Proteoglycans and Their Roles
Proteoglycan 4 (PRG4) has shown potential in making current chemotherapy drugs (like sorafenib) more effective by interfering with cancer cell resistance.