1. Pilling Them Softly -

Critics and fans often cite the episode for its sharp commentary on over-medication and its use of the 250th milestone to blend classic character rivalries with timely pop culture parodies.

" Pilling Them Softly " is the first episode of the 14th season of and its 250th episode overall, airing originally on September 27, 2015. The episode features two main plotlines: 1. Pilling Them Softly

: The soundtrack includes "Pump Up the Jam" by Technotronic during Peter's show and "Thunder in Your Heart" by Stan Bush during the cooking montage. Critics and fans often cite the episode for

: The episode ends with Peter and Quagmire getting fired together after they perform a joint imitation of celebrity chef Paula Deen. airing originally on September 27